Chloe Sherman (Kiera Allen), the protagonist of Run, is a differently abled teenage girl who lives a quiet, reclusive life with her mother Diane (Sarah Paulson) at their rural home in Washington State. Bright, talented and home educated by the devoted Diane, Chloe has been plagued by illness literally since birth: diabetes, asthma, and cardiac arrhythmia are among the issues she deals with daily, not to mention being confined to a wheelchair due to the loss of use of her legs.